Sounds like Sir Anthony Hopkins wants to wrap the story up with a final sequel. Hopefully it deals with why he became a serial killer. That was revealed in the novel of Hannibal, but never was mentioned in the film version. Here's the news from Dark Horizons.
Hannibal 4: The Star has more details on the supposed fourth Lecter adventure, turns out its not what you may think. It seems that 64-year actor Anthony Hopkins wrote a script which would finish up the character once and for all by having Clarice Starling shoot him to death in the final scenes: "I did write a screenplay of my own, just as an exercise, that would follow Hannibal, I showed it to Dino and to my agent and the studio. It's about Hannibal actually out there, after Hannibal. The final denouement. Clarice is having a nervous breakdown and living in San Francisco. Then the nightmares start. She sees him on street corners, and he vanishes in the crowd. Then one night she wakes up in her bedroom and she's handcuffed to her bed, and he's in the corner smoking a cigar, and he says, 'Hello, Clarice..."."
MTFBWY and HH!!
Jar Jar Binks