A doctor (Boris Karloff) developing a serum to reverse old age uses blood from an executed murderer as a medium and begins to exhibit homicidal tendencies after injecting himself with the concoction in the boring 1940 horror movie Before I Hang.
A clean-cut, respectful young man and gun enthusiast with a wife and an all-American family wakes up one morning and goes on a shooting spree, indiscriminately killing men, women, and children in the excellent 1968 horror movie Targets. Writer-director-actor Peter Bogdanovich juxtaposes and intertwines this modern real-life horror tale with the story of the retirement of a fictitious Hollywood horror actor and icon “Byron Orlok” (wonderfully portrayed by Boris Karloff) who feels that the rubber-faced monsters and mad scientists he often plays on screen are no longer effective in a world rocked by real horror - senseless violence committed by seemingly ordinary people. Inspired by the 1966 sniper shootings from the clock tower at the University of Texas, this film also features future producer Frank Marshall in a bit role as the ticket boy at a drive-in. Marshall later went on the produce such mega-hits as Raiders of the Lost Ark, The Goonies, and Back to the Future.