... they'd be shooting themselves in the foot.
I read the article that's linked on the main page (actually before seeing it here), and thought of what a joke Comic-Con in Anaheim would be. True, there's a bigger convention center. But the city lacks atmosphere. It's Disneyland, a few hotels and restaurants, and, well, that's it.
I can't help but wonder how Disneyland would feel about a huge, incredibly popular convention eating up hotel rooms during a prime summer week. I wouldn't think Disneyland would get extra business from outside the area during Comic-Con, as folks visiting probably won't have time and/or money to stop by there.
If they do wind up moving to be closer to the Hollywood studios, I propose they drop the word "Comic" from the name altogether. I doubt I'd be visiting in Anaheim; if it weren't for Disneyland, I doubt I'd even drive through there.